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BDBM50365953 CHEMBL1956225

SMILES: COc1cc2nncc(-c3ccc(NC4CC4)nc3)c2cc1OC

InChI Key: InChIKey=HZLNDSMTJBCSHU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50365953
PNG
(CHEMBL1956225)
Show SMILES COc1cc2nncc(-c3ccc(NC4CC4)nc3)c2cc1OC
Show InChI InChI=1S/C18H18N4O2/c1-23-16-7-13-14(10-20-22-15(13)8-17(16)24-2)11-3-6-18(19-9-11)21-12-4-5-12/h3,6-10,12H,4-5H2,1-2H3,(H,19,21)
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 36.9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE10A


Bioorg Med Chem Lett 22: 2262-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.086
BindingDB Entry DOI: 10.7270/Q2ZK5H42
More data for this
Ligand-Target Pair