BDBM50365964 CHEMBL1956235::CHEMBL2070530

SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC

InChI Key InChIKey=CDCZTLPFRMEYFM-UHFFFAOYSA-N

Data  1 KI  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50365964   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKi:  1.18nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  3.47nMAssay Description:Displacement of [3H]5-(6,7-dimethoxycinnolin-4-yl)-N-isopropyl-3-methylpyridin-2-amine from PDE10A in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human truncated CM5-labeled PDE10A by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant PDE10A using cAMP as substrate incubated for 30 mins prior to substrate addition measured after 3 hrs to overnight by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataKd:  0.940nMAssay Description:Binding affinity to PDE10A in Sprague-Dawley rat striatum by TopCount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed