BindingDB PrimarySearch

BDBM24226 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine::ASTEMIZOLE::Astemizole, [O-Methyl-3H]::CHEMBL296419::Hismanal::Histaminos::[3H]-ASTEMIZOLE::[3H]Astemizole::cid_2247::med.21724, Compound Astemizole

SMILES: COc1ccc(cc1)CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(cc5)F

InChI Key: InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N

Data: 19 KI 42 IC50 3 Kd 4 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 68 hits for monomerid = 24226
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ATP-dependent translocase ABCB1 (Mouse)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycine receptor subunit alpha-1 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a
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Polycomb protein EED (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Heparanase (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.03	n/a	n/a	n/a	n/a	n/a	n/a
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Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bovine)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
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Multidrug and toxin extrusion protein 1 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Mouse)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Guinea pig)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.912	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ubiquitin-conjugating enzyme E2 N (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
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Orf1a protein (MERS-CoV)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.88E+3	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	5.59E+3	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	305	n/a	n/a	n/a	n/a	n/a	n/a
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HLA class I histocompatibility antigen, A alpha chain (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Human)	BDBM24226 (cid_2247 \| [3H]-ASTEMIZOLE \| Hismanal \| ASTEMIZOLE...) Show SMILES Show InChI	GoogleScholar	UniChem	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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