BDBM50367847 CHEMBL4167509

SMILES CC(=O)N([C@@H]1CC[C@@H](CC1)Nc1ccc(cn1)C#N)c1ccc(cc1)-c1cnn(C)c1

InChI Key InChIKey=JNKXYDCPHHUMKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50367847   

TargetCyclin-dependent kinase 12(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367847(CHEMBL4167509)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367847(CHEMBL4167509)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed