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ADENOSINE DIPHOSPHATE ADP::CHEBI:114275

Data: 2 KI  2 IC50  1 Kd  14 EC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match
png missing

Other Databases links: CHEBI PubChem cid PubChem sid

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50368125    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NT


(RAT)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
0.91n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method


Citation and Details

More data for this
Ligand-Target Pair
Ketopantoate reductase


(Escherichia coli (strain K12))
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
1050000.0n/an/an/an/an/an/an/an/a



University Chemical Laboratory

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli KPR


Citation and Details

More data for this
Ligand-Target Pair
Purinergic receptor P2Y1


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 8000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 6


(Rattus norvegicus)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 11000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 3


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>100000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 )


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Rattus norvegicus)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 28000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM,expressed in Xenopus oocytes


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 1


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 10000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 5


(Rattus norvegicus)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 18000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)


Citation and Details

More data for this
Ligand-Target Pair
Ketopantoate reductase


(Escherichia coli (strain K12))
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/a 360000n/an/an/an/an/a



University Chemical Laboratory

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli KPR


Citation and Details

More data for this
Ligand-Target Pair
Heat shock protein 90 beta


(Canis familiaris)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 21000n/an/an/an/a



Infinity Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of BODIPY-AG binding to dog Grp94


Citation and Details

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y6


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 65000n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production


Citation and Details

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitati...


Citation and Details

More data for this
Ligand-Target Pair
Purinergic receptor P2Y12


(Rattus norvegicus)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 69n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)


Citation and Details

More data for this
Ligand-Target Pair
Purinergic receptor P2Y11


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1700n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresc...


Citation and Details

More data for this
Ligand-Target Pair
Purinergic, P2Y


(HUMAN)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 24n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresce...


Citation and Details

More data for this
Ligand-Target Pair
Heat shock protein 75 kDa, mitochondrial


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/a 55594.0n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...


Citation and Details

More data for this
Ligand-Target Pair
Heat shock protein 90 beta


(Canis familiaris)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/a 11447.0n/an/an/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...


Citation and Details

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>100000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)


Citation and Details

More data for this
Ligand-Target Pair
P2X purinoceptor 2


(Homo sapiens)
ADENOSINE DIPHOSPHATE
PNG
(ADP | CHEBI:114275)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
IUPHAR‑DB
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
KEGG
PC cid
PC sid
PDB

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>100000n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against recombinant human receptor P2X purinoceptor 2 (P2X2 )


Citation and Details

More data for this
Ligand-Target Pair