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BDBM50369279 CHEMBL4166454

SMILES: COc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccc(Cl)cc1

InChI Key: InChIKey=BYYRNPIGDRRGLJ-UHFFFAOYSA-N

Data: 1 KI  1 Kd

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50369279   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chemokine CXCL12


(Homo sapiens (Human))
BDBM50369279
PNG
(CHEMBL4166454)
Show SMILES COc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13ClN2O3/c1-23-16-8-11(4-7-15(16)21)14-9-13(19-17(22)20-14)10-2-5-12(18)6-3-10/h2-9,21H,1H3,(H,19,20,22)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
267n/an/an/an/an/an/an/an/a



UMR7200 CNRS/Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Binding affinity to Texas Red-labelled CXCL12 (unknown origin) assessed as inhibition of CXCL12-Texas Red binding to EGFP-labeled human CXCR4 express...


J Med Chem 61: 7671-7686 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00657
BindingDB Entry DOI: 10.7270/Q2QF8WDS
More data for this
Ligand-Target Pair
Chemokine CXCL12


(Homo sapiens (Human))
BDBM50369279
PNG
(CHEMBL4166454)
Show SMILES COc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13ClN2O3/c1-23-16-8-11(4-7-15(16)21)14-9-13(19-17(22)20-14)10-2-5-12(18)6-3-10/h2-9,21H,1H3,(H,19,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 780n/an/an/an/an/a



UMR7200 CNRS/Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Binding affinity to CXCL12 (unknown origin) assessed as changes in tryptophan fluorescence intensity


J Med Chem 61: 7671-7686 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00657
BindingDB Entry DOI: 10.7270/Q2QF8WDS
More data for this
Ligand-Target Pair