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BDBM50369373 CHEMBL1790743

SMILES: CC[C@@H](C)[C@@H](CN(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS

InChI Key: InChIKey=TWVORKFQPZIXTE-RQXATKFSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50369373   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50369373
PNG
(CHEMBL1790743)
Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS
Show InChI InChI=1S/C23H40N4O4S/c1-4-16(2)20(25-13-18(24)15-32)14-27(3)21(12-17-8-6-5-7-9-17)22(29)26-19(10-11-28)23(30)31/h5-9,16,18-21,25,28,32H,4,10-15,24H2,1-3H3,(H,26,29)(H,30,31)/t16-,18-,19+,20-,21+/m1/s1
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase


J Med Chem 41: 2651-6 (1998)


Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV
More data for this
Ligand-Target Pair