BDBM50370603 CHEMBL4167315::US10954217, Example 00225

SMILES COc1cccc(c1)-c1ccc2CN(Cc3ccccc3)Cc2c1

InChI Key InChIKey=LGSGJWDXMWVXEB-UHFFFAOYSA-N

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50370603   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  4.10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  65nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]-Nisoxetine from human NET receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  390nMAssay Description:Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  875nMAssay Description:Displacement of [3H]-LSD from human 5-HT5A receptor expressed in Flp-In CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  904nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D4 expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  1.34E+3nMAssay Description:Displacement of [3H]-PK11195 from PBR receptor in rat brain after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  1.44E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  2.16E+3nMAssay Description:Displacement of [3H]-Win35428 from human DAT expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  2.48E+3nMAssay Description:Displacement of [3H]-Citalopram from human SERT receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  2.58E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  2.88E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370603(CHEMBL4167315 | US10954217, Example 00225)
Affinity DataKi:  3.18E+3nMAssay Description:Displacement of [3H]-U69593 from human KOR expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed