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BDBM50375941 CHEMBL261149

SMILES: Cc1ccc(C)c(c1)N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1

InChI Key: InChIKey=FLTBGIMBKXIGKE-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50375941   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50375941
PNG
(CHEMBL261149)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
Show InChI InChI=1S/C31H34FN5O2/c1-22-10-11-23(2)28(19-22)36-17-15-35(16-18-36)14-6-9-30(38)33-21-29-34-27-13-12-24(32)20-26(27)31(39)37(29)25-7-4-3-5-8-25/h3-5,7-8,10-13,19-20H,6,9,14-18,21H2,1-2H3,(H,33,38)
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Sharif University of Technology

Curated by ChEMBL


Assay Description
Inhibition of 5HT7 receptor by radioligand binding assay


Eur J Med Chem 44: 1463-70 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.050
BindingDB Entry DOI: 10.7270/Q2QV3NRM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50375941
PNG
(CHEMBL261149)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
Show InChI InChI=1S/C31H34FN5O2/c1-22-10-11-23(2)28(19-22)36-17-15-35(16-18-36)14-6-9-30(38)33-21-29-34-27-13-12-24(32)20-26(27)31(39)37(29)25-7-4-3-5-8-25/h3-5,7-8,10-13,19-20H,6,9,14-18,21H2,1-2H3,(H,33,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor


Bioorg Med Chem 16: 2570-8 (2008)


Article DOI: 10.1016/j.bmc.2007.11.049
BindingDB Entry DOI: 10.7270/Q2JW8FRT
More data for this
Ligand-Target Pair