BDBM50377986 CHEMBL483406::UR-AK24
SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1
InChI Key InChIKey=NTHUVTORAXKPJS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50377986
Affinity DataEC50: 15nMAssay Description:Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...More data for this Ligand-Target Pair
Affinity DataEC50: 68nMAssay Description:Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rateMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...More data for this Ligand-Target Pair
Affinity DataEC50: 67nMAssay Description:Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human histamine H2 receptor expressed in Sf9 cells coexpressing Gsalphas by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 15.3nMAssay Description:Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...More data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 15.8nMAssay Description:Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activityMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 1.35E+3nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activityMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gsalpha2, Gbeta1gamma2 and RGS19 by steady-state GTPase activity ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.45nMAssay Description:Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase act...More data for this Ligand-Target Pair