BDBM50378824 CHEMBL1242367

SMILES CCNc1cc(N[C@@H]2CC[C@H](O)CC2)nc(Nc2ccc3n(Cc4ccccc4)ccc3c2)n1

InChI Key InChIKey=YVXCDLCJCIDFHE-DKXQDJALSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50378824   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GST-tagged human CDK1/cyclinB expressed in sf9 cells using GST-pRb as substrate by [gamma-33P]ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GST-tagged human CDK2/cyclinE expressed in sf9 cells using GST-pRb as substrate by [gamma-33P]ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50378824(CHEMBL1242367)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of GST-tagged human CDK4/cyclinD1 expressed in sf9 cells using GST-pRb as substrate by [gamma-33P]ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed