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BDBM50380631 CHEMBL2017070

SMILES: COc1cc2CCn3cnc(-c4cocn4)c3-c2cc1OC

InChI Key: InChIKey=SVRMHFXMIQWERK-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380631   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50380631
PNG
(CHEMBL2017070)
Show SMILES COc1cc2CCn3cnc(-c4cocn4)c3-c2cc1OC
Show InChI InChI=1S/C16H15N3O3/c1-20-13-5-10-3-4-19-8-17-15(12-7-22-9-18-12)16(19)11(10)6-14(13)21-2/h5-9H,3-4H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
508n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay


Bioorg Med Chem Lett 22: 2585-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.113
BindingDB Entry DOI: 10.7270/Q2319WX5
More data for this
Ligand-Target Pair