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BDBM50380689 CHEMBL2017504

SMILES: CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cc2ccccc2s1

InChI Key: InChIKey=GCUPSMOTKGQOJO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380689   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380689
PNG
(CHEMBL2017504)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1cc2ccccc2s1
Show InChI InChI=1S/C20H22FO3PS/c1-3-23-25(22,24-4-2)18(13-15-9-11-17(21)12-10-15)20-14-16-7-5-6-8-19(16)26-20/h5-12,14,18H,3-4,13H2,1-2H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair