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BDBM50380701 CHEMBL2017657

SMILES: CCOP(=O)(OCC)C(Cc1cc(F)cc(F)c1)c1sc2ccccc2c1C

InChI Key: InChIKey=QVXHAEQGELTBNQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380701   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380701
PNG
(CHEMBL2017657)
Show SMILES CCOP(=O)(OCC)C(Cc1cc(F)cc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23F2O3PS/c1-4-25-27(24,26-5-2)19(12-15-10-16(22)13-17(23)11-15)21-14(3)18-8-6-7-9-20(18)28-21/h6-11,13,19H,4-5,12H2,1-3H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair