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BDBM50380713 CHEMBL2017671

SMILES: CC(C)OP(=O)(OC(C)C)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C

InChI Key: InChIKey=DQBJKVNKQOHWGV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380713   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380713
PNG
(CHEMBL2017671)
Show SMILES CC(C)OP(=O)(OC(C)C)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C23H27F2O3PS/c1-14(2)27-29(26,28-15(3)4)21(13-17-10-11-19(24)20(25)12-17)23-16(5)18-8-6-7-9-22(18)30-23/h6-12,14-15,21H,13H2,1-5H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair