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BDBM50380715 CHEMBL2017673

SMILES: CCOP(=O)(OCC)C(c1ccccc1)c1ccc(Br)cc1

InChI Key: InChIKey=PCYRFMVFIJMRNJ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50380715   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380715
PNG
(CHEMBL2017673)
Show SMILES CCOP(=O)(OCC)C(c1ccccc1)c1ccc(Br)cc1
Show InChI InChI=1S/C17H20BrO3P/c1-3-20-22(19,21-4-2)17(14-8-6-5-7-9-14)15-10-12-16(18)13-11-15/h5-13,17H,3-4H2,1-2H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair