BDBM50381716 ABT-348::ILORASERTIB::US8722890, 1::US8722890, 2

SMILES: Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12

InChI Key: InChIKey=WPHKIQPVPYJNAX-UHFFFAOYSA-N

Data: 2 KI  48 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 50381716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.59	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase JAK3 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aurora kinase A (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lck (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
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ALK tyrosine kinase receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	363	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	456	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	539	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase JAK2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 9 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 alpha (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.87	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.65	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.1	25
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.42	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.22	n/a	n/a	n/a	n/a	7.1	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.13	n/a	n/a	n/a	n/a	7.1	25
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19.5	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27.3	n/a	n/a	n/a	n/a	7.1	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.73	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	675	n/a	n/a	n/a	n/a	7.4	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.74E+3	n/a	n/a	n/a	n/a	7.4	n/a
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Cytochrome P450 3A4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	37
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Cytochrome P450 3A4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
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Cytochrome P450 3A4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
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Cytochrome P450 3A4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek4 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek2 (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50381716 (US8722890, 1 | US8722890, 2 | ABT-348 | ILORASERTI...) Show SMILES Show InChI	GoogleScholar	UniChem		3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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