BDBM50382491 CHEMBL2024114::US10988455, Example 1(xlii)

SMILES Nc1nnc(-c2ccc(O)c(Cl)c2)c(n1)-c1ccccc1

InChI Key InChIKey=ZHUZHTHIEMXLRA-UHFFFAOYSA-N

Data  6 KI

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50382491   

TargetAdenosine receptor A1(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  0.145nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  0.162nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  1.38nMAssay Description:All test compounds were prepared as a stock solution of 10 mM in 100% DMSO.Inhibition binding assays were performed using 2.5 μg of membranes pr...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  1.41nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membrane incubated for 1 hr by microplate beta scintillation ...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50382491(CHEMBL2024114 | US10988455, Example 1(xlii))
Affinity DataKi:  4nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair