BDBM50382559 ISPINESIB

SMILES CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1

InChI Key InChIKey=QJZRFPJCWMNVAV-HHHXNRCGSA-N

Data  3 KI  9 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50382559   

TargetKinesin-like protein KIF11(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Kinesin Eg5 (unknown origin)More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.30nMAssay Description:Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataKi:  2.5nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50:  4.81E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50:  2.43E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50:  5nMAssay Description:Inhibition of C-terminal His-tagged microtubule-stimulated KSP motor domain (1 to 369) ATPase activity (unknown origin) preincubated for 30 mins foll...More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50:  47nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
TargetKinesin-like protein KIFC1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50382559(ISPINESIB)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed