BDBM50382959 CEP-32496::CHEMBL2029988::US9730937, Example 261

SMILES: COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC

InChI Key: InChIKey=DKNUPRMJNUQNHR-UHFFFAOYSA-N

Data: 20 IC50  42 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 62 hits for monomerid = 50382959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cytochrome P450 2C9 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 3 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-A receptor 2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ALK tyrosine kinase receptor (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase ABL1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a
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IGF-like family receptor 1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase JAK2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	513	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cytochrome P450 2C19 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<250	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<250	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<250	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	375	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<250	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<250	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50382959 (CEP-32496 | CHEMBL2029988 | US9730937, Example 261) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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