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BDBM50383176 CHEMBL2031908

SMILES: COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1

InChI Key: InChIKey=ZKRUOFXSJYQEJY-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50383176   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.10E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.35E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair