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BDBM50383216 CHEMBL2032178

SMILES: Fc1ccc(cc1)C1N(CCc2sccc12)C(=O)Nc1ccccc1

InChI Key: InChIKey=COZAUGRKNQCDCG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50383216   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383216
PNG
(CHEMBL2032178)
Show SMILES Fc1ccc(cc1)C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H17FN2OS/c21-15-8-6-14(7-9-15)19-17-11-13-25-18(17)10-12-23(19)20(24)22-16-4-2-1-3-5-16/h1-9,11,13,19H,10,12H2,(H,22,24)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.84E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair