BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002

SMILES: CN1CCN(CC1)c2ccc(c(c2)OC)Nc3ncc(c(n3)Oc4cccc(c4)NC(=O)C=C)Cl

InChI Key: InChIKey=ITTRLTNMFYIYPA-UHFFFAOYSA-N

Data: 53 IC50  8 Kd  6 EC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 91 hits for monomerid = 50383274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NUAK family SNF1-like kinase 1 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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eIF-2-alpha kinase GCN2 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase DCLK3 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-G-associated kinase (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.24E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 1 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	756	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NUAK family SNF1-like kinase 2 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Focal adhesion kinase 1 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase PLK4 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50383274 (CHEMBL1229592 | US9670213, WZ4002 | US10167264, WZ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair