BDBM50386451 CHEMBL2047685

SMILES ONC(=O)CCCNC(=O)C(Cc1ccc(O)c(Br)c1)N=O

InChI Key InChIKey=XNLSRQMULSCIQC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50386451   

TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50:  310nMAssay Description:Inhibition of Bordetella sp. (strain FB188) N-terminus His-tagged HDAH expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50386451(CHEMBL2047685)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed