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BDBM50389035 CHEMBL2064419

SMILES: O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1

InChI Key: InChIKey=FPFCFOIMTFHSNY-UHFFFAOYSA-N

Data: 11 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50389035   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 118n/an/an/an/an/an/a



Sanofi Research & Development

Curated by ChEMBL


Assay Description
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 42n/an/an/an/an/an/a



Sanofi Research & Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 2.13E+3n/an/an/an/an/an/a



Sanofi Research & Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi Research & Development

Curated by ChEMBL


Assay Description
Inhibition of mTOR


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi Research & Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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Article
PubMed
n/an/a 2.14E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 118n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of mTOR


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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n/an/a 42n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair