BDBM50389186 CHEMBL2062803::US8501936, 4

SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCOCC3)nc12

InChI Key InChIKey=UUVZHZJBZYONMR-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50389186   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  461nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  0.900nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  61nMAssay Description:Inhibition of JAK2 in human TF-1 cells using GM-CSF pretreated for 1 hr prior to GM-CSF addition measured after 5 hrs by FRET based GeneBLAzer assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human JAK2 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  17nMAssay Description:Inhibition of human JAK3 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389186(CHEMBL2062803 | US8501936, 4)
Affinity DataIC50:  22.5nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent