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BDBM50390142 CHEMBL2069688

SMILES: COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccnc2ccccc12

InChI Key: InChIKey=VAJMNYFMYBAXAB-WYMPLXKRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390142   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Mus musculus)
BDBM50390142
PNG
(CHEMBL2069688)
Show SMILES COC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccnc2ccccc12
Show InChI InChI=1S/C21H20BrN3O4/c1-27-17-10-13(11-18(28-2)19(17)22)12-24-25-21(26)20(29-3)15-8-9-23-16-7-5-4-6-14(15)16/h4-12,20H,1-3H3,(H,25,26)/b24-12+
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 3.90n/an/an/an/an/an/a



Omeros Corp.

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE10A-mediated hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting


Bioorg Med Chem Lett 22: 5595-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.007
BindingDB Entry DOI: 10.7270/Q2X63P65
More data for this
Ligand-Target Pair