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BDBM50390833 CHEMBL2070671

SMILES: COc1cc(F)c2nnc3c(C)nc(-c4sccc4C)n3c2c1

InChI Key: InChIKey=BLODSLLFPYATAO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390833   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50390833
PNG
(CHEMBL2070671)
Show SMILES COc1cc(F)c2nnc3c(C)nc(-c4sccc4C)n3c2c1
Show InChI InChI=1S/C16H13FN4OS/c1-8-4-5-23-14(8)16-18-9(2)15-20-19-13-11(17)6-10(22-3)7-12(13)21(15)16/h4-7H,1-3H3
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 9.43n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysis


Bioorg Med Chem Lett 22: 5876-84 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.076
BindingDB Entry DOI: 10.7270/Q2FB5413
More data for this
Ligand-Target Pair