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BDBM50391892 CHEMBL2147531

SMILES: NCCNc1nc(cc2ccccc12)-c1ccncc1

InChI Key: InChIKey=CMPYJCKDXNDOGF-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50391892   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C, eta


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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Article
PubMed
n/an/a 743n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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Article
PubMed
n/an/a 877n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
PDB
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PC cid
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UniChem

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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair