BDBM17950 (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide::ALISKIREN FUMARATE::Aliskiren::Aliskiren Hemifumarate::CHEMBL1639::Rasilez::TEKTURNA

SMILES: COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)ccc1OC

InChI Key: InChIKey=UXOWGYHJODZGMF-UHFFFAOYSA-N

Data: 37 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 17950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Rat)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin-1 (Mouse)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Rabbit)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cathepsin D (Bovine)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Crab-eating macaque)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Pepsin A (Pig)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	2.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Rhesus macaque)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Rat)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.2	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Renin (Human)	BDBM17950 (CHEMBL1639 | Rasilez | (2S,4S,5S,7S)-5-amino-N-(2-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair