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BDBM50394025 CHEMBL2158478

SMILES: Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CC1

InChI Key: InChIKey=NDLBUZLXSKJVNF-SYWLJEDYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394025   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50394025
PNG
(CHEMBL2158478)
Show SMILES Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CC1
Show InChI InChI=1S/C19H25N3O2/c1-10-20-9-15(17(21-10)12-2-3-12)18(23)22-16-13-4-11-5-14(16)8-19(24,6-11)7-13/h9,11-14,16,24H,2-8H2,1H3,(H,22,23)/t11?,13?,14?,16-,19-
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 395n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by HTRF assay


Bioorg Med Chem Lett 22: 6756-61 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.070
BindingDB Entry DOI: 10.7270/Q23R0V0G
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50394025
PNG
(CHEMBL2158478)
Show SMILES Cc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CC1
Show InChI InChI=1S/C19H25N3O2/c1-10-20-9-15(17(21-10)12-2-3-12)18(23)22-16-13-4-11-5-14(16)8-19(24,6-11)7-13/h9,11-14,16,24H,2-8H2,1H3,(H,22,23)/t11?,13?,14?,16-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of mouse 11betaHSD1 by HTRF assay


Bioorg Med Chem Lett 22: 6756-61 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.070
BindingDB Entry DOI: 10.7270/Q23R0V0G
More data for this
Ligand-Target Pair