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BDBM50394551 CHEMBL2159089

SMILES: OC[C@H]1O[C@@H](Oc2[nH]nc(C3CC3)c2Cc2ccccc2OCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key: InChIKey=MAAKWWYJBOXEMO-IUMGNVSONA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394551   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50394551
PNG
(CHEMBL2159089)
Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(C3CC3)c2Cc2ccccc2OCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C26H30N2O7/c29-13-20-22(30)23(31)24(32)26(34-20)35-25-18(21(27-28-25)16-10-11-16)12-17-8-4-5-9-19(17)33-14-15-6-2-1-3-7-15/h1-9,16,20,22-24,26,29-32H,10-14H2,(H,27,28)/t20-,22-,23+,24-,26+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 278n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)


Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50394551
PNG
(CHEMBL2159089)
Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(C3CC3)c2Cc2ccccc2OCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C26H30N2O7/c29-13-20-22(30)23(31)24(32)26(34-20)35-25-18(21(27-28-25)16-10-11-16)12-17-8-4-5-9-19(17)33-14-15-6-2-1-3-7-15/h1-9,16,20,22-24,26,29-32H,10-14H2,(H,27,28)/t20-,22-,23+,24-,26+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.56E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake


Bioorg Med Chem 20: 6598-612 (2012)


Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36
More data for this
Ligand-Target Pair