BDBM50394726 CHEMBL2165819

SMILES Nc1c(cnc2ccnn12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key InChIKey=BWUXSHHOKODNAK-HDJSIYSDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50394726   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50394726(CHEMBL2165819)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50394726(CHEMBL2165819)
Affinity DataIC50:  78nMAssay Description:Inhibition of human DGAT1 expressed in human HeLa cells assessed as reduction in triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50394726(CHEMBL2165819)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant DGAT1 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50394726(CHEMBL2165819)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse DGAT1 using [1-14C]decanoyl-CoA substrate by phospholipid flash plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50394726(CHEMBL2165819)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant DGAT2 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid flash plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed