BDBM50395253 CHEMBL2164684

SMILES Fc1ccc2c3CN(CCc3[nH]c2c1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N

InChI Key InChIKey=MIOKYZZTPMKVEG-IAGOWNOFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50395253   

TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395253(CHEMBL2164684)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395253(CHEMBL2164684)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395253(CHEMBL2164684)
Affinity DataIC50: >2.90E+3nMAssay Description:Inhibition of human recombinant CatB assessed as suppression of enzyme-mediated Z-Arg-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed