BDBM50396169 CHEMBL1337170

SMILES [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI Key InChIKey=ZRRGOUHITGRLBA-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50396169   

TargetHypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 670nMAssay Description:Inhibition of STAT3 in human Hep3B cells assessed as inhibition of IL-6 stimulated STAT3 expression by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataKd:  1.53E+3nMAssay Description:Binding affinity to His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3 SH2 domain using 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2 as substrate preincubated for 60 mins prior to substrate addition by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3-SH2 (unknown origin) using 5-carboxyfluorescein-GY(PO3H2)EEIP as substrate incubated with compound for 1 hr followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Binding affinity to STAT3 in human NIH-3T3 cells assessed as STAT3 stabilization incubated for 1 hr by CETSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of STAT3 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of IFNgamma-stimulated GFP/FLAG-tagged STAT3 dimerization in human AD293 cells incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 6.30E+3nMAssay Description:Antagonist activity at human vasopressin V1a receptor by cell based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 3(Human)
Universita Paul Sabatier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396169BDBM50396169(CHEMBL1337170)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of STAT3 (unknown origin) expressed in mouse NIH3T3 cells assessed as reduction in DNA binding activity incubated for 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed