BDBM50396263 CHEMBL2172315

SMILES CC(C)NC(=O)[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cc(F)cc(F)c2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12

InChI Key InChIKey=GZYCQQBRSRIFII-JAQLMMITSA-N

Data  3 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50396263   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  0.240nMAssay Description:Binding affinity to human ALK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  72nMAssay Description:Binding affinity to human MER by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  25nMAssay Description:Binding affinity to human MAP4K2 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to human LTK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  110nMAssay Description:Binding affinity to human LCK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  72nMAssay Description:Binding affinity to human INSR by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to human AXL by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataIC50:  536nMAssay Description:Inhibition of INSR expressed in CHO cells assessed as inhibition of receptor phosphorylation pre-incubated before insulin stimulation by Meso-Scale D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  5.60nMAssay Description:Binding affinity to human IRAK1 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed