BindingDB PrimarySearch

BDBM50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB

SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F

InChI Key: InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N

Data: 89 IC50 7 Kd 8 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 108 hits for monomerid = 50396483
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [416-766,V600E] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	25
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RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	25
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Muscarinic acetylcholine receptor M1 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M2 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M3 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
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Muscarinic acetylcholine receptor M1 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	790	n/a	n/a	n/a	25
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Serine/threonine-protein kinase B-raf [409-765] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	344	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Discoidin domain-containing receptor 2 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [696-1022,L858R] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase A-Raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Mouse)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Pirin (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Serine/threonine-protein kinase A-Raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase A-Raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50396483 (PLX-4032 \| RG 7204 \| Ro 5185426 \| VEMURAFENIB \| US...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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