BDBM50396934 CHEMBL2001019::CHEMBL2170804::US9062045, Comparator No. 3 (PF-04217903)
SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
InChI Key InChIKey=PDMUGYOXRHVNMO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 50396934
Affinity DataEC50: 0.300nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of His6-tagged human c-Met H1094R mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human c-Met H1094R mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human c-Met H1094R mutant expressed in mouse NIH3T3 cells assessed as reduction in HGF-stimulated c-Met phosphorylation incubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 4.5nMAssay Description:Binding affinity to human c-Met catalytic domain (1051-1348 residues) expressed in Sf9 cells by SPRMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated HUVEC cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Inhibition of recombinant human c-Met in presence of NADH by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of wild type endogenous c-Met in human A549 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed by 2...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human HT-29 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of wild type human c-Met expressed in human T47D cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated mIMCD3 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of un -tagged wild type human c-Met expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4Tyr) ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of His6-tagged wild type human c-Met expressed in Sf9 cells using (Glu4Tyr) or Met2 peptide substrate by coupled enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human U87 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human MDA-MB-231 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human A549 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human COLO 205 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human NCI-H441 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human NCI-H1993 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated human GTL 16 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of c-Met phosphorylation in HGF-stimulated dog MDCK cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of wild type human c-Met expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human c-Met M1250T mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human c-Met M1250T mutant expressed in mouse NIH3T3 cells assessed as reduction in HGF-stimulated c-Met phosphorylation incubated for 1...More data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of His6-tagged human c-Met Y1235D mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 139nMAssay Description:Inhibition of human c-Met Y1235D mutant expressed in human T47D cells assessed as reduction in HGF-stimulated c-Met phosphorylation incubated for 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 142nMAssay Description:Inhibition of human c-Met Y1235D mutant expressed in human T47D cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr foll...More data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Inhibition of His6-tagged human c-Met L1195V mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataKi: 3.90E+3nMAssay Description:Inhibition of His6-tagged human c-Met Y1230H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Affinity DataKi: 9.40E+3nMAssay Description:Inhibition of His6-tagged human c-Met Y1230C mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of His6-tagged human c-Met D1228H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Insulin receptor expressed in HEK293 cells assessed as reduction insulin-stimulated INSR phosphorylation incubated for 1 hr by sandwich...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MER expressed in HEK293 cells assessed as reduction in Gas6-stimulated MER phosphorylation incubated for 1 hr by sandwich ELISA analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AXL expressed in HEK293 cells assessed as reduction in Gas6-stimulated AXL phosphorylation incubated for 1 hr by sandwich ELISA analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Ron expressed in mouse NIH3T3 cells assessed as reduction in MSP-stimulated RON phosphorylation incubated for 1 hr by sandwich ELISA an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Met Y1230C mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SLC34A2-Ros phosphorylation in human HCC87 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NPM-ALK phosphorylation in human KARPAS-299 cells incubated for 1 hr by sandwich ELISA analysisMore data for this Ligand-Target Pair