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BDBM50396949 CHEMBL2170811

SMILES: COc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=JMFRERGITRZIIC-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50396949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396949
PNG
(CHEMBL2170811)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)11-24-18-17(22-23-24)20-10-16(21-18)13-4-6-14(19)7-5-13/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
73n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396949
PNG
(CHEMBL2170811)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)11-24-18-17(22-23-24)20-10-16(21-18)13-4-6-14(19)7-5-13/h2-10H,11H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.92E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair