BDBM50397771 CHEMBL2059300::US9593129, Example 67

SMILES CC[C@H](N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C

InChI Key InChIKey=BTIJKFCQUAULPU-YEPCPMPXSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50397771   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataKd:  1nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  1.00E+3nMAssay Description:Activity at p53 in human HCT116 cells expressing wild type p53 assessed as induction of p21 mRNA expression after 7 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  2nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  20nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50:  1.90E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed