BDBM50398016 CHEMBL2180412::US9018217, 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine::US9592230, 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine

SMILES Cc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12

InChI Key InChIKey=OVVMSTOLRDQFRD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50398016   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50398016(CHEMBL2180412 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  7.20nMT: 2°CAssay Description:A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50398016(CHEMBL2180412 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  7.20nMAssay Description:A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM50398016(CHEMBL2180412 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of PDE10A using [3H]cAMP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed