BDBM50398609 CHEMBL2141296::IXAZOMIB CITRATE::Ixazomib::MLN2238::NINLARO::US12054502, Compound Ixazomib

SMILES: B([C@H](CC(C)C)NC(=O)CNC(=O)c1cc(ccc1Cl)Cl)(O)O

InChI Key: InChIKey=MXAYKZJJDUDWDS-UHFFFAOYSA-N

Data: 21 IC50  1 EC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50398609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NACHT, LRR and PYD domains-containing protein 3 (Mouse)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proteasome subunit beta type-2 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proteasome subunit beta type-1 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Proteasome subunit beta type-7 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Proteasome subunit beta type-6 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proteasome subunit beta type-8 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proteasome subunit beta type-10 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aminopeptidase N (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325 / PS 47))	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325 / PS 47))	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50398609 (CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair