BDBM50398666 CHEMBL2178136::US8791130, 2

SMILES CNc1nc(Nc2ccc(cc2Cl)-c2nnnn2C)ncc1C(F)(F)F

InChI Key InChIKey=WWSWXMYEELUOBP-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50398666   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398666(CHEMBL2178136 | US8791130, 2)
Affinity DataKi:  7nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398666(CHEMBL2178136 | US8791130, 2)
Affinity DataKi:  8nMAssay Description:Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398666(CHEMBL2178136 | US8791130, 2)
Affinity DataIC50:  100nMAssay Description:Inhibition of autophosphorylation of LRRK2 in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed