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BDBM50398737 CHEMBL2179637

SMILES: OC(=O)c1cc(F)cc(c1)-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1

InChI Key: InChIKey=JHBVDFXAWLGDRG-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50398737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50398737
PNG
(CHEMBL2179637)
Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1
Show InChI InChI=1S/C27H24FNO4/c28-22-12-19(11-20(13-22)27(31)32)18-5-3-4-17(10-18)16-33-24-8-9-25-21(14-24)15-29(26(25)30)23-6-1-2-7-23/h3-5,8-14,23H,1-2,6-7,15-16H2,(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay


J Med Chem 55: 9434-45 (2012)


Article DOI: 10.1021/jm3005306
BindingDB Entry DOI: 10.7270/Q2RX9D78
More data for this
Ligand-Target Pair