BDBM50401421 CHEMBL2207503
SMILES Cc1nn(C)cc1-c1nc2ncc(Cl)c(N3CCN(Cc4ccc(Cl)cc4)CC3)c2[nH]1
InChI Key InChIKey=AKJBLKUZXRMECW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50401421
Affinity DataKd: 48nMAssay Description:Binding affinity to Aurora B kinaseMore data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding affinity to Aurora B (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP2A6 by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataKd: 7.5nMAssay Description:Binding affinity to Aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Inhibition of Aurora B kinase-mediated Histone H3 phosphorylation at S10 in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Binding affinity to Aurora A kinaseMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERG by whole-cell voltage clampingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using mephenytoin as a substrate by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 by LC-MS-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 by LC-MS-MS analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataKd: 6.20nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataKd: 6.20nMAssay Description:Binding affinity to FLT3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 7.5nMAssay Description:Binding affinity to Aurora A (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at T288 in human HeLa cellsMore data for this Ligand-Target Pair