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BDBM50402574 CHEMBL2205557

SMILES: CCCCc1sc(nc1-c1ccc(OCC2CCCN(CC)C2)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key: InChIKey=FDQHNDVVDQCJSB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50402574   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Advanced glycosylation end product-specific receptor


(Homo sapiens)
BDBM50402574
PNG
(CHEMBL2205557)
Show SMILES CCCCc1sc(nc1-c1ccc(OCC2CCCN(CC)C2)cc1)-c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H37ClN2O2S/c1-3-5-8-31-32(25-9-15-28(16-10-25)37-23-24-7-6-21-36(4-2)22-24)35-33(39-31)26-11-17-29(18-12-26)38-30-19-13-27(34)14-20-30/h9-20,24H,3-8,21-23H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 1.91E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Antagonist activity at human biotinylated RAGE assessed as inhibition of amyloid beta binding after 60 mins by ELISA


Bioorg Med Chem Lett 22: 7555-61 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.022
BindingDB Entry DOI: 10.7270/Q2XG9S9S
More data for this
Ligand-Target Pair