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BDBM50405949 CHEMBL2114408

SMILES: ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(O)=O)Cc1ccccc1

InChI Key: InChIKey=VBZAORRCTGPSQY-MSOLQXFVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50405949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50405949
PNG
(CHEMBL2114408)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c24-19(23-28)13-17(11-15-7-3-1-4-8-15)21(27)22-18(14-20(25)26)12-16-9-5-2-6-10-16/h1-10,17-18,28H,11-14H2,(H,22,27)(H,23,24)(H,25,26)/t17-,18+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50405949
PNG
(CHEMBL2114408)
Show SMILES ONC(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c24-19(23-28)13-17(11-15-7-3-1-4-8-15)21(27)22-18(14-20(25)26)12-16-9-5-2-6-10-16/h1-10,17-18,28H,11-14H2,(H,22,27)(H,23,24)(H,25,26)/t17-,18+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]-D-Ala2-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair