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BDBM50411759 CHEMBL258263

SMILES: CNC(=O)c1cc2c(nc(C)cn2c1)C#Cc1cccc(F)c1

InChI Key: InChIKey=HNUPRYGERDVHFY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50411759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50411759
PNG
(CHEMBL258263)
Show SMILES CNC(=O)c1cc2c(nc(C)cn2c1)C#Cc1cccc(F)c1
Show InChI InChI=1S/C18H14FN3O/c1-12-10-22-11-14(18(23)20-2)9-17(22)16(21-12)7-6-13-4-3-5-15(19)8-13/h3-5,8-11H,1-2H3,(H,20,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR


Bioorg Med Chem Lett 18: 1804-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.024
BindingDB Entry DOI: 10.7270/Q27945W4
More data for this
Ligand-Target Pair