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BDBM50413465 CHEMBL558605

SMILES: C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(C[N+]4(C)CCNCC4)c3)ccc2F)CCN1

InChI Key: InChIKey=NDAMODMAZTURFF-FQKVKQEKNA-O

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50413465   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413465
PNG
(CHEMBL558605)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(C[N+]4(C)CCNCC4)c3)ccc2F)CCN1
Show InChI InChI=1/C32H40FN5O/c1-24-21-37(14-11-35-24)22-26-5-3-7-28(17-26)30-19-25(9-10-31(30)33)20-36-32(39)29-8-4-6-27(18-29)23-38(2)15-12-34-13-16-38/h3-10,17-19,24,34-35H,11-16,20-23H2,1-2H3/p+1/t24-/s2
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Similars

Article
PubMed
n/an/an/a 3.16n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair