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BDBM50414558 CHEMBL556496

SMILES: COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1

InChI Key: InChIKey=CUOZZEMLTFRECQ-UHFFFAOYSA-N

Data: 4 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50414558   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
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25.1n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
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25.1n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human DRD2 receptor by GTPgammaS binding assay


Bioorg Med Chem Lett 19: 5056-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.055
BindingDB Entry DOI: 10.7270/Q2PR7X7C
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
631n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human DRD3 receptor by GTPgammaS binding assay


Bioorg Med Chem Lett 19: 5056-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.055
BindingDB Entry DOI: 10.7270/Q2PR7X7C
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
631n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
PDB
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Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG


Bioorg Med Chem Lett 19: 5056-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.055
BindingDB Entry DOI: 10.7270/Q2PR7X7C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50414558
PNG
(CHEMBL556496)
Show SMILES COc1cccc(c1)C1CCCN(CCN2CCN(C2=O)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C23H28ClN3O2/c1-29-22-9-2-5-18(15-22)19-6-4-10-25(17-19)11-12-26-13-14-27(23(26)28)21-8-3-7-20(24)16-21/h2-3,5,7-9,15-16,19H,4,6,10-14,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair